Intravenous (IV) ketamine infusions are effective for chronic pain syndromes, especially those syndromes that have a neuropathic component, such as complex regional pain syndrome (CRPS), post-herpetic neuralgia, and neuropathic pain from peripheral nerve damage. There is no consensus in the medical literature on administration protocol, but the studies have shown that the duration of pain relief is related to duration of the ketamine infusion. Because of this, we have a different treatment protocol for our patients that we treat for chronic pain, compared to our depression treatment protocol. Our protocol for administering IV ketamine for chronic pain takes approximately twice as long per treatment compared to our depression protocol, and we recommend a series of infusions as part of the initial treatment. When patients are assessed in our office we discuss the specifics of the protocol further. All of our treatments are individualized on a case-by-case-basis depending of a number of factors.