Intravenous (IV) ketamine treatment for depression is, “perhaps the most important breakthrough in antidepressant treatment in decades,” according to the former NIMH director, Dr. Tom Insel. I fully agree with Dr. Insel’s suggestion. Although the use of IV ketamine for depression is not FDA approved, research over the past decade has proven that it is a very safe and effective treatment for depression, alleviating severe symptoms of depression in a matter of hours to days for the majority of patients. Additionally, there is a growing body of evidence that suggests IV ketamine infusions are effective for other psychiatric conditions such as Post-traumatic Stress Disorder (PTSD), and Obsessive Compulsive Disorder (OCD). Because ketamine is a generic medication, it is highly unlikely that any pharmaceutical companies will invest the enormous amount of time and money that is required to obtain FDA approval.